A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery

Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (37), p.6265-6268
Main Authors: Chu, Liping, Gao, Honglin, Cheng, Tangjian, Zhang, Yumin, Liu, Jinjian, Huang, Fan, Yang, Cuihong, Shi, Linqi, Liu, Jianfeng
Format: Article
Language:English
Subjects:
Antibiotics
Charge
Circulation
Conversion
Nanostructure
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Summary:Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc01269h