Convenient synthesis of antiproliferative 2,3-dihydro-2,3′-bisindoles via dimerization of N-H indole derivatives

[Display omitted] A convenient and efficient approach for the synthesis of 2,3-dihydro-2,3′-bisindoles has been developed in good yields via dimerization of N-H indole derivatives. The synthetic utility of this approach was demonstrated by the rapid construction of bisindoles in gram-scale. Biologic...

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Bibliographic Details
Published in:Tetrahedron letters 2016-03, Vol.57 (10), p.1097-1099
Main Authors: Guo, Tao, Han, Shu-Lei, Liu, Ying-Chao, Liu, Yu, Liu, Hong-Min
Format: Article
Language:English
Subjects:
2,3-Dihydro-2,3′-bisindole
Antiproliferative activity
Antiproliferatives
Biotechnology
Derivatives
Dimerization
Indoles
MTT assay
Synthesis
Tetrahedrons
Utilities
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Summary:[Display omitted] A convenient and efficient approach for the synthesis of 2,3-dihydro-2,3′-bisindoles has been developed in good yields via dimerization of N-H indole derivatives. The synthetic utility of this approach was demonstrated by the rapid construction of bisindoles in gram-scale. Biological evaluation revealed that some of the obtained 2,3-dihydro-2,3′-bisindoles exhibited significant in vitro antiproliferative activities on human-derived lung, liver, stomach, and breast cancer cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.01.093