Asarotonide, a new phenylpropanoid with a rare natural acetonide group from the rhizomes of Acorus gramineus

[Display omitted] •A new phenylpropanoid with a rare natural acetonide group was isolated.•The structure of the new compound was established by extensive NMR data and HR-MS.•The cytotoxic activities of the compounds were tested against human cancer cells.•The inhibitory activities on NO production w...

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Bibliographic Details
Published in:Tetrahedron letters 2016-04, Vol.57 (15), p.1699-1701
Main Authors: Yu, Jae Sik, Moon, Eunjung, Choi, Sang Un, Kim, Ki Hyun
Format: Article
Language:English
Subjects:
Acorus gramineus
Activated
Antiproliferation
Antiproliferatives
Asarotonide
Biotechnology
Cancer
Human
Nitric oxide
Phenylpropanoid
Spectroscopy
Tetrahedrons
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Summary:[Display omitted] •A new phenylpropanoid with a rare natural acetonide group was isolated.•The structure of the new compound was established by extensive NMR data and HR-MS.•The cytotoxic activities of the compounds were tested against human cancer cells.•The inhibitory activities on NO production were evaluated in microglial cell line. A new phenylpropanoid with a rare natural acetonide group, asarotonide, together with three known phenylpropanoids were isolated from the rhizomes of Acorus gramineus. The structure of the new compound was established by extensive spectroscopic data and HR-MS. The antiproliferative activities of the compounds were tested against human cancer cell lines; in addition, inhibitory activities on nitric oxide production were evaluated in an activated murine microglial cell line.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.03.010