Evidence for possible role of toll-like receptor 3 mediating virus-induced progression of pituitary adenomas

Tumor-related viruses are known to be involved in initiation and progression of certain tumors. However, the relationship between virus and pituitary adenomas (PAs) remains unknown. Here, we investigated infection status of three types of viruses (HPV16, HHV6B and HSV1) and expression level of toll-...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2016-05, Vol.426, p.22-32
Main Authors: Zheng, Xin, Li, Song, Zang, Zhenle, Hu, Jintao, An, Jiayin, Pei, Xiangdong, Zhu, Feng, Zhang, Weihua, Yang, Hui
Format: Article
Language:English
Subjects:
Activation analysis
Adenoma - metabolism
Adenoma - pathology
Adenoma - virology
Adult
Aged
Animals
Apoptosis
Biotechnology
Cell Line, Tumor
Cell Proliferation
Disease Progression
Female
Herpes simplex virus 1
Herpesvirus 6, Human - physiology
Human papillomavirus 16
Human papillomavirus 16 - physiology
Humans
Immune systems
Male
Middle Aged
Papillomavirus Infections - metabolism
Papillomavirus Infections - pathology
Pathways
Pituitary adenoma
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Pituitary Neoplasms - virology
Progression
Progressions
Proteins
Rats
Roseolovirus Infections - metabolism
Roseolovirus Infections - pathology
Signal Transduction
Survival
Toll-like receptor 3
Toll-Like Receptor 3 - metabolism
Viruses
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Summary:Tumor-related viruses are known to be involved in initiation and progression of certain tumors. However, the relationship between virus and pituitary adenomas (PAs) remains unknown. Here, we investigated infection status of three types of viruses (HPV16, HHV6B and HSV1) and expression level of toll-like receptor 3 (TLR3) in 60 human PA samples. We also determined the role of TLR3 signaling pathway on a PA cell line (GH3). We firstly found that positive rates of HPV16 and HHV6B infection were significantly higher in invasive PA samples than in noninvasive samples (P 
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2016.02.009