Functional regulatory roles of microRNAs in atherosclerosis

MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3′UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a c...

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Bibliographic Details
Published in:Clinica chimica acta 2016-09, Vol.460, p.164-171
Main Authors: Gao, Ya, Peng, Juan, Ren, Zhong, He, Ni-ya, Li, Qing, Zhao, Xue-shan, Wang, Mei-mei, Wen, Hong-yan, Tang, Zhi-han, Jiang, Zhi-sheng, Wang, Gui-xue, Liu, Lu-shan
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis - genetics
Endothelial cells
Endothelial Cells - pathology
Humans
Inflammation
Macrophages
Macrophages - pathology
microRNA
MicroRNAs - physiology
Molecular Targeted Therapy - methods
Muscle, Smooth, Vascular - pathology
Vascular smooth muscle cells
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Summary:MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3′UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a complex disease, atherosclerosis is influenced by a combination of multiple genes and environmental factors. Both of them play a role in atherogenesis by affecting different types of cells (such as endothelial cell, vascular smooth muscle cell and monocyte/macrophage) function. MicroRNAs control the senescence and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, and macrophage-driven cytokine production and polarization. By these effects, microRNAs can influence the processes of atherosclerosis and may represent new molecular targets for therapy. •Major cells in atherosclerosis plaque are regulated by microRNAs.•MicroRNAs can influence the processes of atherosclerosis.•MicroRNAs may represent new molecular targets for atherosclerosis prevention and therapy.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2016.06.044