DNA injury is acutely enhanced in response to increasing bulks of aerobic physical exercise

The aim of this study was to evaluate DNA damage in response to increasing bulks of aerobic physical exercise. Fifteen adult and trained athletes performed four sequential trials with increasing running distance (5-, 10-, 21- and 42-km) in different periods of the year. The γ-H2AX foci parameters we...

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Bibliographic Details
Published in:Clinica chimica acta 2016-09, Vol.460, p.146-151
Main Authors: Lippi, Giuseppe, Buonocore, Ruggero, Tarperi, Cantor, Montagnana, Martina, Festa, Luca, Danese, Elisa, Benati, Marco, Salvagno, Gian Luca, Bonaguri, Chiara, Roggenbuck, Dirk, Schena, Federico
Format: Article
Language:English
Subjects:
Adult
Aerobic physical exercise
Athletes
DNA
DNA Damage
Exercise
Histones - analysis
Humans
Injury
Running
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Summary:The aim of this study was to evaluate DNA damage in response to increasing bulks of aerobic physical exercise. Fifteen adult and trained athletes performed four sequential trials with increasing running distance (5-, 10-, 21- and 42-km) in different periods of the year. The γ-H2AX foci parameters were analyzed before and 3h after the end of each trial. The values of all γ-H2AX foci parameters were enhanced after the end of each trial, with values gradually increasing from the 5- to the 42-km trial. Interestingly, a minor increase of γ-H2AX foci was still evident after 5- to 10-km running, but a much higher increase occurred when the running distance exceeded 21km. The generation of DNA injury was then magnified by running up to 42-km. The increase of each γ-H2AX foci parameter was then found to be associated with both running distance and average intensity. In multivariate linear regression analysis, the running distance was significantly associated with average intensity and post-run variation in the percentage of cells with γ-H2AX foci. We can hence conclude that aerobic exercise may generate an acute DNA damage in trained athletes, which is highly dependent upon running distance and average intensity. •Controversy remains about the appropriate amount of physical exercise.•We observed increase DNA injury after aerobic exercise.•DNA injury was associated with running distance and average intensity.•Aerobic exercise may generate an acute DNA damage in trained athletes.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2016.06.041