Acute effects of a dopamine/norepinephrine reuptake inhibitor on neuromuscular performance following self-paced exercise in cool and hot environments

• Published in: Journal of thermal biology 2016-08, Vol.60, p.60-69
• Main Authors: Onus, Katrina, Cannon, Jack, Liberts, Liz, Marino, Frank E.
• Format: Article
• Language: English
• Subjects: acute effects; Adolescent; Adult; Bicycling - physiology; Body Temperature Regulation - drug effects; Bupropion - administration & dosage; Bupropion - pharmacology; dopamine; Dopamine - metabolism; Dopamine Uptake Inhibitors - administration & dosage; Dopamine Uptake Inhibitors - pharmacology; Exercise; heart rate; Heart Rate - drug effects; heat; Hot Temperature; Humans; Male; males; motivation; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; norepinephrine; Norepinephrine - metabolism; placebos; skeletal muscle; skin temperature; Skin Temperature - drug effects; thermoregulation; Young Adult
• ISSN: 0306-4565; 1879-0992
• DOI: 10.1016/j.jtherbio.2016.06.003

Dopamine/norepinephrine (DA/NE) reuptake inhibitors have been used to manipulate the central mechanisms affecting arousal and motivation during exercise. Eight healthy, physically active males performed 30min fixed-intensity cycling at 50% Wmax followed by 30min of self paced time trial (TT) with each section interspersed with a 30 s maximal sprint at 9, 19 and 29min. The DA/NE re-uptake inhibitor administered was bupropion (BUP) versus a placebo (PLA) in either warm (32°C, BUP32 or PLA32) or moderate (20°C; BUP20, PLA20) ambient conditions. Core and skin temperature, heart rate and perceptual responses, neuromuscular and hormonal measures were assessed at multiple times throughout the trials and post exercise. Time trial performance remained unchanged across conditions (12.7–13.1km) although core temperature was elevated in the fixed intensity section of the trials for BUP32 and BUP20 but continued to rise only in BUP32 during the time trial reaching 38.6°C (P