Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells

Abstract Cancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In f...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2016-08, Vol.82, p.555-560
Main Authors: dos Santos, Thiago André R, da Silva, Aline Caroline, Silva, Elany Barbosa, Gomes, Paulo André Teixeira de Moraes, Espíndola, José Wanderlan Pontes, Cardoso, Marcos Veríssimo de Oliveira, Moreira, Diogo Rodrigo Magalhaes, Leite, Ana Cristina Lima, Pereira, Valéria R.A
Format: Article
Language:English
Subjects:
1,3-thiazoles
Animals
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Cancer
Cell death
Drug development
HT29 Cells
Humans
Immune system
Immunologic Factors - pharmacology
Interleukin-10 - biosynthesis
Internal Medicine
Jurkat Cells
Macrophages - drug effects
Macrophages - metabolism
Medical Education
Mice
Thiazoles - chemical synthesis
Thiazoles - chemistry
Thiazoles - pharmacology
Thiosemicarbazones
Thiosemicarbazones - chemical synthesis
Thiosemicarbazones - chemistry
Thiosemicarbazones - pharmacology
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:Abstract Cancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In fact, there are a number of mechanisms underlying the role immune system plays in tumor cells. In this work, we describe the structural design, synthesis, antitumor and immunomodulatory potential of 31 new 1,3-thiazole and thiosemicarbazone compounds. Cisplatin was used as anticancer drug control. Cytotoxicity against J774A.1 macrophages and antitumor activity against HT-29 and Jurkat cells was determined. These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis. In addition, these compounds, especially pyridyl-thiazoles compounds, regulated immune factors such as interleukin 10 and tumor necrosis factor, possible by directing immune system in favor of modulating cancer cell proliferation. By examining their pharmacological activity, we were able to identify new potent and selective anticancer compounds.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2016.05.038