FDG PET/CT in Acute Tumefactive Multiple Sclerosis Occurring in a Case of Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

ABSTRACTTumefactive multiple sclerosis refers to the presentation of large demyelinating lesions (≥2 cm in diameter) mimicking brain tumors clinically and radiologically. We present the MRI and FDG PET/CT findings in a case with tumefactive multiple sclerosis, who had chronic graft-versus-host disea...

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Bibliographic Details
Published in:Clinical nuclear medicine 2016-09, Vol.41 (9), p.e414-e416
Main Authors: Dong, Aisheng, Gao, Mingjun, Wang, Yang, Gao, Lei, Zuo, Changjing
Format: Article
Language:English
Subjects:
Adolescent
Biopsy
Fluorodeoxyglucose F18
Graft vs Host Disease - diagnostic imaging
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Leukemia, Myeloid, Acute - therapy
Magnetic Resonance Imaging
Male
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - etiology
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Transplantation, Homologous - adverse effects
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Summary:ABSTRACTTumefactive multiple sclerosis refers to the presentation of large demyelinating lesions (≥2 cm in diameter) mimicking brain tumors clinically and radiologically. We present the MRI and FDG PET/CT findings in a case with tumefactive multiple sclerosis, who had chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Head MRI showed 7 cerebral lesions with incomplete ring enhancement. All but one lesion had size more than 2 cm. All these demyelinating lesions showed increased uptake at the rims of the lesions with central hypometabolism. Stereotactic brain biopsy of the right frontal lesion revealed extensive macrophage and lymphocyte infiltration.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000001193