Ewing sarcoma: a chronicle of molecular pathogenesis

Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific geneti...

Full description

Saved in:
Bibliographic Details
Published in:Human pathology 2016-09, Vol.55, p.91-100
Main Authors: Kim, Sang Kyum, MD, PhD, Park, Yong-Koo, MD, PhD
Format: Article
Language:English
Subjects:
12E7 Antigen - analysis
Angiogenesis
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Bone Neoplasms - chemistry
Bone Neoplasms - genetics
Bone Neoplasms - pathology
Cell division
Chromosomal translocation
Chromosome Aberrations
Chromosomes
Diagnosis, Differential
Epigenesis, Genetic
Epigenetics
Ewing sarcoma
Gene Expression Regulation, Neoplastic
Genes
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Leukemia
Lymphoma
Molecular Diagnostic Techniques
Molecular pathogenesis
Pathogenesis
Pathology
Phenotype
Predictive Value of Tests
Prognosis
Protein expression
Proteins
Sarcoma, Ewing - chemistry
Sarcoma, Ewing - genetics
Sarcoma, Ewing - pathology
Studies
Transcription, Genetic
Translocation, Genetic
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family ( TLS/FUS, EWSR1, and TAF15 ) and genes of the ETS (E26 transformation-specific) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2016.05.008