Correlation Between the Clinical Parameters and Tissue Phenotype in Patients Affected by Deep-Infiltrating Endometriosis

The current study aimed to identify and validate an applicable immunohistochemistry panel including Ki-67, c-MYC, estrogen receptor-α (ER-α), and progesterone receptor isoforms A/B (PR-A/B) in correlation with clinicopathological parameters in patients affected by deep infiltrating endometriosis. Ti...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2016-09, Vol.23 (9), p.1258-1268
Main Authors: Vinci, Giovanna, Arkwright, Sylviane, Audebourg, Anne, Radenen, Brigitte, Chapron, Charles, Borghese, Bruno, Dousset, Bertrand, Mehats, Celine, Vaiman, Daniel, Vacher-Lavenu, Marie-Cécile, Gogusev, Jean
Format: Article
Language:English
Subjects:
Adult
DNA-Binding Proteins - metabolism
Embryology
Endometriosis - diagnosis
Endometriosis - metabolism
Endometriosis - pathology
Estrogen Receptor alpha - metabolism
Female
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Medicine & Public Health
Microvessels - metabolism
Obstetrics/Perinatology/Midwifery
Original Artide
Phenotype
Receptors, Progesterone - metabolism
Reproductive Medicine
Tissue Array Analysis
Transcription Factors - metabolism
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Summary:The current study aimed to identify and validate an applicable immunohistochemistry panel including Ki-67, c-MYC, estrogen receptor-α (ER-α), and progesterone receptor isoforms A/B (PR-A/B) in correlation with clinicopathological parameters in patients affected by deep infiltrating endometriosis. Tissue microarrays were prepared from a cohort of 113 patients. Phenotypic profile of the panel molecules was evaluated in glands and stroma in parallel with microvessels and stroma density measurements. Principal component analysis was performed on 8 immunohistochemical variables, 2 histological variables, and 8 subgroups of clinical parameters. The immunohistochemical profiling showed consistent Ki-67 immunostaining in 17.9% of the samples and c-MYC in 83.1%, while intense ER-α immunoreactivity was detected in 84% of the samples and PR-A/B isoforms in 24.1% of them. The combination of clinical parameters and tissue phenotype allowed a stratification of endometriosis-affected patients. Such novel phenotypical and clinical correlation could be helpful in the future studies for a better stratification of the disease aiming at a personalized patient care.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719116638188