Involvement of nitric oxide on the peritoneal neutrophil influx induced by staphylococcal enterotoxin B in mouse

In this study, the role of nitric oxide (NO) on neutrophil migration induced by staphylococcal enterotoxin B (SEB) in the mouse peritoneal cavity was investigated. The NO synthase inhibitors L-NAME and aminoguanidine, as well as dexamethasone, markedly reduced SEB-induced neutrophil influx. In mice...

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Bibliographic Details
Published in:Toxicon (Oxford) 2001-09, Vol.39 (9), p.1383-1386
Main Authors: Franco-Penteado, C.F., DeSouza, I., Teixeira, S.A., Ribeiro-DaSilva, G., De Nucci, G., Antunes, E.
Format: Article
Language:English
Subjects:
Aminoguanidine
Animals
Anti-Inflammatory Agents - pharmacology
Bacteriology
Biological and medical sciences
Cell Movement - drug effects
Dexamethasone - pharmacology
Enterotoxins
Enterotoxins - toxicity
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
Guanidines - pharmacology
Inflammation
Male
Mice
Microbiology
Neutrophil Infiltration - physiology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - physiology
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Nitric oxide synthases
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Peritoneum - cytology
staphylococcal enterotoxin B
Staphylococcus
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Summary:In this study, the role of nitric oxide (NO) on neutrophil migration induced by staphylococcal enterotoxin B (SEB) in the mouse peritoneal cavity was investigated. The NO synthase inhibitors L-NAME and aminoguanidine, as well as dexamethasone, markedly reduced SEB-induced neutrophil influx. In mice with an increased population of peritoneal macrophages, the inhibition of SEB-induced neutrophil influx by these agents was significantly lower. The in vivo treatment with aminoguanidine inhibited only the iNOS activity, whereas L-NAME inhibited both the cNOS and iNOS activities. In conclusion, NO modulates the neutrophil migration in response to SEB through the activity of an iNOS isoform.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(01)00095-2