A TP-FRET-based two-photon fluorescent probe for ratiometric visualization of endogenous sulfur dioxide derivatives in mitochondria of living cells and tissues

A ratiometric two-photon fluorescent probe for SO 2 derivatives was first proposed based on acedan-merocyanine dyads via a TP-FRET strategy. It was successfully applied to visualization of the fluctuations of enzymatically generated SO 2 derivatives in the mitochondria of HepG2 cells and rat liver t...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-08, Vol.52 (67), p.1289-1292
Main Authors: Yang, Xiaoguang, Zhou, Yibo, Zhang, Xiufang, Yang, Sheng, Chen, Yun, Guo, Jingru, Li, Xiaoxuan, Qing, Zhihe, Yang, Ronghua
Format: Article
Language:English
Subjects:
Cells (biology)
Derivatives
Fluorescence
Microscopy
Mitochondria
Strategy
Sulfur dioxide
Visualization
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Summary:A ratiometric two-photon fluorescent probe for SO 2 derivatives was first proposed based on acedan-merocyanine dyads via a TP-FRET strategy. It was successfully applied to visualization of the fluctuations of enzymatically generated SO 2 derivatives in the mitochondria of HepG2 cells and rat liver tissues using two-photon fluorescence microscopy imaging. A TP-FRET-based ratiometric two-photon fluorescent probe for endogenous SO 2 derivative imaging in mitochondria has been developed for the first time.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc05254a