Alzheimer's disease: Is this a brain specific diabetic condition?

Abstract Alzheimer's disease (AD) and type 2 diabetes (T2DM) are the two major health issues affecting millions of elderly people worldwide, with major impacts in the patient's daily life. Numerous studies have demonstrated that patients with diabetes have an increased risk of developing A...

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Bibliographic Details
Published in:Physiology & behavior 2016-10, Vol.164 (Pt A), p.259-267
Main Authors: Rani, Vanita, Deshmukh, Rahul, Jaswal, Priya, Kumar, Puneet, Bariwal, Jitender
Format: Article
Language:English
Subjects:
Alzheimer disease
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Animals
Aβ pathology
Brain - drug effects
Brain - metabolism
Cognitive deficit
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Humans
Insulin resistance
Neurodegeneration
Psychiatry
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Summary:Abstract Alzheimer's disease (AD) and type 2 diabetes (T2DM) are the two major health issues affecting millions of elderly people worldwide, with major impacts in the patient's daily life. Numerous studies have demonstrated that patients with diabetes have an increased risk of developing AD compared with healthy individuals. The principal biological mechanisms that associate with the progression of diabetes and AD are not completely understood. Impaired insulin signaling, uncontrolled glucose metabolism, oxidative stress, abnormal protein processing, and the stimulation of inflammatory pathways are common features to both AD and T2DM. In recent years brain specific abnormalities in insulin and insulin like growth factor (IGF) signaling considered as a major trigger involved in the etiopathogenesis of AD, showing T2DM like milieu. This review summarizes the pathways that might link diabetes and AD and the effect of diminished insulin.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2016.05.041