Development of the adaptive NK cell response to human cytomegalovirus in the context of aging

Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with...

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Published in:Mechanisms of ageing and development 2016-09, Vol.158, p.23-26
Main Authors: López-Botet, Miguel, Muntasell, Aura, Martínez-Rodríguez, José E., López-Montañés, María, Costa-García, Marcel, Pupuleku, Aldi
Format: Article
Language:English
Subjects:
Age
Aging - immunology
Aging - pathology
Animals
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - pathology
Humans
Immunity
Immunity, Cellular
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Mice
Natural killer cells
NK Cell Lectin-Like Receptor Subfamily D - immunology
NKG2C
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Summary:Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence and an increase mortality rate in elderly people. Such long-term detrimental effects of the viral infection presumably result from an inefficient immune control of the pathogen, depending on the quality and evolution of the individual host-pathogen relationship. Together with antigen-specific T lymphocytes, NK cells play an important role in anti-viral immune defense. HCMV promotes in some individuals the differentiation and persistent steady state expansion of an NK cell subset bearing the CD94/NKG2C activating receptor. The relationship between this adaptive NK cell response to HCMV and aging is overviewed.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2016.06.010