Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis

Abstract Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL c...

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Bibliographic Details
Published in:Atherosclerosis 2016-08, Vol.251, p.438-444
Main Authors: Botta, Eliana, Meroño, Tomás, Saucedo, Carla, Martín, Maximiliano, Tetzlaff, Walter, Sorroche, Patricia, Boero, Laura, Malah, Verónica, Menafra, Martín, Gómez Rosso, Leonardo, Chapman, John M, Kontush, Anatol, Soriano, Enrique, Brites, Fernando
Format: Article
Language:English
Subjects:
Aged
Anthropometry
Antioxidants - chemistry
Apolipoprotein A-I - metabolism
Arterial rigidity
Arteries - pathology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - physiopathology
Aryldialkylphosphatase - blood
Atherosclerosis
Biomarkers - blood
Cardiovascular
Cardiovascular Diseases - metabolism
Cholesterol Ester Transfer Proteins - blood
Cholesteryl ester transfer protein
Female
HDL
Healthy Volunteers
Humans
Lipoproteins, HDL - blood
Male
Middle Aged
Paraoxonase
Pulse Wave Analysis
Pulse wave velocity
Rheumatoid arthritis
Severity of Illness Index
Vascular Stiffness
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Summary:Abstract Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL characteristics on arterial stiffness in RA patients classified according to the inflammatory disease activity. Methods RA patients were classified according to disease activity (DAS-28) into active RA (n = 27; DAS-28 > 3.2) and inactive RA patients (n = 17; DAS-28 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2016.06.009