Using metabolomics to dissect host–parasite interactions

Highlights • Metabolomic approaches have highlighted aspects of parasite metabolism essential for virulence. • Most mammalian infective parasite stages are dependent on sugars as primary carbon sources. • Key metabolic fluxes are regulated by metabolic rather than transcriptional mechanisms. • Signi...

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Bibliographic Details
Published in:Current opinion in microbiology 2016-08, Vol.32, p.59-65
Main Authors: Kloehn, J, Blume, M, Cobbold, SA, Saunders, EC, Dagley, MJ, McConville, MJ
Format: Article
Language:English
Subjects:
Animals
Glycolysis - physiology
Host Specificity - physiology
Host-Parasite Interactions - physiology
Leishmania - metabolism
Life Cycle Stages - physiology
Metabolic Networks and Pathways
Metabolomics
Pathology
Plasmodium falciparum - metabolism
Toxoplasma - metabolism
Trypanosoma brucei brucei - metabolism
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Summary:Highlights • Metabolomic approaches have highlighted aspects of parasite metabolism essential for virulence. • Most mammalian infective parasite stages are dependent on sugars as primary carbon sources. • Key metabolic fluxes are regulated by metabolic rather than transcriptional mechanisms. • Significant differences in host and parasite central carbon metabolism offer opportunities for drug development.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2016.04.019