Minireview: Syndecans and their crucial roles during tissue regeneration

Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Sy...

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Bibliographic Details
Published in:FEBS letters 2016-08, Vol.590 (15), p.2408-2417
Main Authors: Chung, Heesung, Multhaupt, Hinke A. B., Oh, Eok‐Soo, Couchman, John R.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - genetics
Cell Differentiation - genetics
Cell Proliferation - genetics
extracellular matrix
growth factor
Humans
Inflammation - genetics
Ligands
Regeneration - genetics
Signal Transduction
syndecan
Syndecans - genetics
Wound Healing
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Summary:Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.12280