Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology

Abstract Background and aims Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). Methods Gal-3BP plasma l...

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Bibliographic Details
Published in:Atherosclerosis 2016-08, Vol.251, p.94-100
Main Authors: Gleissner, Christian A, Erbel, Christian, Linden, Fabian, Domschke, Gabriele, Akhavanpoor, Mohammadreza, Doesch, Andreas O, Buss, Sebastian J, Giannitsis, Evangelos, Katus, Hugo A, Korosoglou, Grigorios
Format: Article
Language:English
Subjects:
Aged
Antigens, Neoplasm - blood
Atherosclerosis - physiopathology
Biomarker
Biomarkers, Tumor - blood
Cardiovascular
Carotid Artery Diseases - blood
Carrier Proteins - blood
CCTA
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - mortality
Enzyme-Linked Immunosorbent Assay
Female
Galectin-3 binding protein
Glycoproteins - blood
Humans
Male
Middle Aged
Outcome
Plaque morphology
Plaque, Atherosclerotic - blood
Proportional Hazards Models
Risk Factors
Ventricular Function, Left
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Summary:Abstract Background and aims Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). Methods Gal-3BP plasma levels were measured by ELISA in 233 patients (63 ± 10 years, 50.2% male) undergoing computed coronary angiography tomography (CCTA). Results In 149 patients, CCTA confirmed CAD (stenosis grade >20%). Mean Gal-3BP plasma levels were 5.9 ± 2.7 μg/mL and did not differ between patients with or without CAD. Over a follow-up time of up to 4.4 years (median 2.5 years), there were 17 cases of revascularization, five cases of myocardial infarction, and five deaths (four non-cardiac, one fatal myocardial infarction). Kaplan-Meier analysis revealed that high Gal-3BP levels were significantly associated with long-term mortality ( p  
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2016.06.002