Epinephrine and Left Atrial and Left Ventricular Diastolic Function Decrease in Normal Subjects

Abstract Background We assessed the effect of epinephrine over left atrial and left ventricular diastolic function in subjects without structural heart disease. Methods Twenty-seven, 34.6 ± 17.2 year-old patients without structural heart disease were included. Intravenous epinephrine (50 to 100 ng/K...

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Bibliographic Details
Published in:International journal of cardiology 2016-10, Vol.220, p.333-336
Main Authors: Fuenmayor, Abdel J, Solórzano, Moisés I, Gómez, Luisangelly
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atrial function
Atrial Function, Left - drug effects
Atrial Function, Left - physiology
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular
Diastole - drug effects
Diastole - physiology
Diastolic function
Echocardiography
Echocardiography - drug effects
Epinephrine
Epinephrine - administration & dosage
Female
Humans
Infusions, Intravenous
Left
Male
Middle Aged
Vasoconstrictor Agents - administration & dosage
Ventricular function
Ventricular Function, Left - drug effects
Ventricular Function, Left - physiology
Young Adult
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Summary:Abstract Background We assessed the effect of epinephrine over left atrial and left ventricular diastolic function in subjects without structural heart disease. Methods Twenty-seven, 34.6 ± 17.2 year-old patients without structural heart disease were included. Intravenous epinephrine (50 to 100 ng/Kg/min) was infused. Left atrial and ventricular function were evaluated by means of echocardiography before and during the epinephrine infusion. Results No complications were observed. Significant increases in heart rate and systolic blood pressure were recorded. Both left atrial (minimal and maximal) volumes increased but increase in the minimal volume was more pronounced, and the ejection fraction diminished. Left atrial expansion index decreased and the fraction of left ventricular inflow volume resulting from atrial contraction increased. Two patients displayed abnormal left ventricular diastolic function. During epinephrine infusion, E/A and e´ decreased, and isovolumetric relaxation time increased. Conclusions In this group of young adults without structural heart disease, epinephrine infusion was safe, did not produce any complications, and induced a small but significant decrease in left atrial function and left ventricular diastolic function.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2016.06.139