SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

Abstract SIRT3 belongs to a highly conserved protein family of histone deacetylases and it is rich in mitochondria. As acetyl-modification is one of the important post-translational modifications that prevail in the mitochondria, it is not surprising that SIRT3 plays a key regulatory role in this or...

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Bibliographic Details
Published in:International journal of cardiology 2016-10, Vol.220, p.700-705
Main Authors: Lu, Yi, Wang, Yi-dong, Wang, Xiao-ya, Chen, Han, Cai, Zhe-jun, Xiang, Mei-xiang
Format: Article
Language:English
Subjects:
Animals
Biphenyl Compounds - pharmacology
Biphenyl Compounds - therapeutic use
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - metabolism
Cellular death
Enzyme Induction - drug effects
Enzyme Induction - physiology
Humans
Ischemia–reperfusion injury
Lignans - pharmacology
Lignans - therapeutic use
Mitochondrial metabolism
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
SIRT3
Sirtuin 3 - metabolism
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Summary:Abstract SIRT3 belongs to a highly conserved protein family of histone deacetylases and it is rich in mitochondria. As acetyl-modification is one of the important post-translational modifications that prevail in the mitochondria, it is not surprising that SIRT3 plays a key regulatory role in this organelle. SIRT3 has a wide range of substrates that are involved in the physiological and pathological processes of oxidative stress, ischemia–reperfusion injury, mitochondrial metabolism homeostasis and cellular death. These pathophysiological processes are considered as the underlying mechanisms of diseases like cardiac hypertrophy, myocardial infarction and heart failure, indicating the potential roles of SIRT3 in cardiovascular diseases. In this review, we will summarize the emerging roles and therapeutic implications of SIRT3 in cardiovascular diseases by providing an update on the latest understanding of its functions.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2016.06.236