Circular RNA expression in cutaneous squamous cell carcinoma

Highlights • CircularRNAs (circRNAs) have pivotal impacts on the cellular regulatory network. • CircRNAs sequester microRNAs (miRNAs) with miRNA response elements (MREs). • A total of 322 circRNAs were identified as differentially expressed in cSCC. • A total of 1603 MREs were identified as part of...

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Bibliographic Details
Published in:Journal of dermatological science 2016-09, Vol.83 (3), p.210-218
Main Authors: Sand, Michael, Bechara, Falk G, Gambichler, Thilo, Sand, Daniel, Bromba, Michael, Hahn, Stephan A, Stockfleth, Eggert, Hessam, Schapoor
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
CircularRNAs
Computational Biology
Cutaneous squamous cell carcinoma
Databases, Genetic
Dermatology
Female
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Humans
Male
MicroRNAs
MicroRNAs - genetics
Middle Aged
Non-coding RNAs
Oligonucleotide Array Sequence Analysis
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA - genetics
RNA, Neoplasm - genetics
Skin Neoplasms - genetics
Skin Neoplasms - pathology
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Summary:Highlights • CircularRNAs (circRNAs) have pivotal impacts on the cellular regulatory network. • CircRNAs sequester microRNAs (miRNAs) with miRNA response elements (MREs). • A total of 322 circRNAs were identified as differentially expressed in cSCC. • A total of 1603 MREs were identified as part of differentially expressed circRNAs. • Complementary MRE sequence was identified in 23 miRNAs known to be cSCC relevant. • CircRNAs are epigenetic players in cSCC which need to be further investigated.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.05.012