A Schistosome-Expressed Immunomodulatory Glycoconjugate Expands Peritoneal Gr1 super(+) Macrophages That Suppress Naive CD4 super(+) T Cell Proliferation Via an IFN- gamma and Nitric Oxide-Dependent Mechanism

Lacto-N-fucopentaose III (LNFPIII) is found in human milk and on the Th2 driving helminth parasite Schistosoma mansoni. This pentasaccharide drives Th2-type responses in vivo and in vitro when conjugated to a carrier. In an attempt to further understand early events in Th1 to Th2 switching, we exami...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2001-10, Vol.167 (8), p.4293-4302
Main Authors: Atochina, O, Daly-Engel, T, Piskorska, D, McGuire, E, Harn, DA
Format: Article
Language:English
Subjects:
g-Interferon
glycoconjugates
Lacto-N-fucopentaose III
Schistosoma mansoni
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lacto-N-fucopentaose III (LNFPIII) is found in human milk and on the Th2 driving helminth parasite Schistosoma mansoni. This pentasaccharide drives Th2-type responses in vivo and in vitro when conjugated to a carrier. In an attempt to further understand early events in Th1 to Th2 switching, we examined phenotypic and functional changes in peritoneal cell populations in BALB/c and SCID mice following LNFPIII-dextran injection. We found that i.p. injection with LNFPIII-dextran resulted in rapid (
ISSN:0022-1767