Immunogenicity and persistence of immunity of a quadrivalent Human Papillomavirus (HPV) vaccine in immunocompromised children

Highlights • HPV is associated with several cancers, including cervical and anogenital cancers. • Immunosuppression can lead to accelerated and earlier onset cancers. • A clinical trial on HPV vaccine was conducted in immunocompromised children. • Vaccine was immunogenic - seroconversion rates rapid...

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Bibliographic Details
Published in:Vaccine 2016-08, Vol.34 (36), p.4343-4350
Main Authors: MacIntyre, C. Raina, Shaw, Peter, Mackie, Fiona E, Boros, Christina, Marshall, Helen, Barnes, Michelle, Seale, Holly, Kennedy, Sean E, Moa, Aye, Hayen, Andrew, Chughtai, Abrar Ahmad, O’Loughlin, Edward V, Stormon, Michael
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Age
Allergy and Immunology
Antibodies, Viral - blood
Arthritis
Australia - epidemiology
Cancer
Cervical cancer
Child
Child, Preschool
Children & youth
Competition
Drug dosages
Female
Females
Girls
Hospitals
Human Papillomavirus
Human papillomavirus 16 - immunology
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - administration & dosage
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - adverse effects
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - immunology
Humans
Immunisation
Immunoassay
Immunocompromised Host
Immunodeficiency
Immunogenicity
Immunogenicity, Vaccine
Immunoglobulins
Inflammatory bowel disease
Male
Males
Papillomaviridae
Papillomavirus Infections - epidemiology
Papillomavirus Infections - immunology
Papillomavirus Infections - prevention & control
Papillomavirus Infections - virology
Seroconversion
Stem cells
Time Factors
Transplants & implants
Vaccination
Vaccine
Vaccines
Warts
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Description
Summary:Highlights • HPV is associated with several cancers, including cervical and anogenital cancers. • Immunosuppression can lead to accelerated and earlier onset cancers. • A clinical trial on HPV vaccine was conducted in immunocompromised children. • Vaccine was immunogenic - seroconversion rates rapidly increased for all serotypes. • More research is needed to inform benefits of HPV vaccine for immunocompromised.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.06.049