Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

This study investigated the effects of dietary proteins on the growth, disease resistance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (264.11 ± 0.76 g) were fed six diets containing graded levels of protein (143.1,...

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Bibliographic Details
Published in:Fish & shellfish immunology 2016-08, Vol.55, p.64-87
Main Authors: Xu, Jing, Wu, Pei, Jiang, Wei-Dan, Liu, Yang, Jiang, Jun, Kuang, Sheng-Yao, Tang, Ling, Tang, Wu-Neng, Zhang, Yong-An, Zhou, Xiao-Qiu, Feng, Lin
Format: Article
Language:English
Subjects:
Aeromonas hydrophila
Aeromonas hydrophila - physiology
Animal Feed - analysis
Animals
Antioxidant
Apoptosis
Carps
Ctenopharyngodon idella
Diet - veterinary
Dietary Proteins - metabolism
Disease resistance
Dose-Response Relationship, Drug
Fish Diseases - immunology
Fish Diseases - microbiology
Fish Proteins - genetics
Fish Proteins - metabolism
Freshwater
Gram-Negative Bacterial Infections - immunology
Gram-Negative Bacterial Infections - microbiology
Gram-Negative Bacterial Infections - veterinary
Grass carp (Ctenopharyngodon idella)
Immunity, Innate
Intestinal immune
Intestines - physiology
Protein
Random Allocation
Signal Transduction
Tight junction
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Summary:This study investigated the effects of dietary proteins on the growth, disease resistance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (264.11 ± 0.76 g) were fed six diets containing graded levels of protein (143.1, 176.7, 217.2, 257.5, 292.2 and 322.8 g digestible protein kg−1 diet) for 8 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila and mortalities were recorded for 14 days. The results indicated that optimal dietary protein levels: increased the production of antibacterial components, up-regulated anti-inflammatory cytokines, inhibitor of κBα, target of rapamycin and ribosomal protein S6 kinases 1 mRNA levels, whereas down-regulated pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) P65, NF-κB P52, c-Rel, IκB kinase β, IκB kinase γ and eIF4E-binding proteins 2 mRNA levels in three intestinal segments of young grass carp (P 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2016.05.021