Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity

Six new physalin steroids, 7β-methoxylisophysalin B (1), 7β-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7–26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were rev...

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Bibliographic Details
Published in:Fitoterapia 2016-07, Vol.112, p.144-152
Main Authors: Yang, Ye-Kun, Xie, Si-da, Xu, Wan-xuan, Nian, Yin, Liu, Xiao-Ling, Peng, Xing-Rong, Ding, Zhong-Tao, Qiu, Ming-Hua
Format: Article
Language:English
Subjects:
Bacillus subtilis
Escherichia coli
Neophysalin
Physalin
Physalis alkekengi
Physalis alkekengi var. franchetii
Steroid
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Summary:Six new physalin steroids, 7β-methoxylisophysalin B (1), 7β-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7–26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 1D and 2D NMR and mass spectroscopic methods. Compounds 1–26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8, 11, and 14 displayed potent cytotoxicities (IC50
ISSN:0367-326X
DOI:10.1016/j.fitote.2016.05.010