Opposite effects of cannabis and cocaine on performance monitoring

Abstract Drug use is often associated with risky and unsafe behavior. However, the acute effects of cocaine and cannabis on performance monitoring processes have not been systematically investigated. The aim of the current study was to investigate how administration of these drugs alters performance...

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Bibliographic Details
Published in:European neuropsychopharmacology 2016-07, Vol.26 (7), p.1127-1139
Main Authors: Spronk, Desirée B, Verkes, Robbert J, Cools, Roshan, Franke, Barbara, Van Wel, Janelle H.P, Ramaekers, Johannes G, De Bruijn, Ellen R.A
Format: Article
Language:English
Subjects:
Brain - drug effects
Brain - physiology
Cannabis
Cocaine
Cocaine - pharmacology
Cross-Over Studies
Dopamine Uptake Inhibitors - pharmacology
Double-Blind Method
Electroencephalography
Error positivity
Error-related negativity
Evoked Potentials - drug effects
Executive Function - drug effects
Executive Function - physiology
Female
Humans
Internal Medicine
Male
Neuropsychological Tests
Performance monitoring
Psychiatry
Psychotropic Drugs - pharmacology
Substance-Related Disorders - physiopathology
Young Adult
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Summary:Abstract Drug use is often associated with risky and unsafe behavior. However, the acute effects of cocaine and cannabis on performance monitoring processes have not been systematically investigated. The aim of the current study was to investigate how administration of these drugs alters performance monitoring processes, as reflected in the error-related negativity (ERN), the error positivity (Pe) and post-error slowing. A double-blind placebo-controlled randomized three-way crossover design was used. Sixty-one subjects completed a Flanker task while EEG measures were obtained. Subjects showed diminished ERN and Pe amplitudes after cannabis administration and increased ERN and Pe amplitudes after administration of cocaine. Neither drug affected post-error slowing. These results demonstrate diametrically opposing effects on the early and late phases of performance monitoring of the two most commonly used illicit drugs of abuse. Conversely, the behavioral adaptation phase of performance monitoring remained unaltered by the drugs.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2016.03.015