Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial

Purpose Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of a...

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Bibliographic Details
Published in:European journal of nutrition 2016-06, Vol.55 (4), p.1633-1644
Main Authors: Libuda, Lars, Mesch, Christina M., Stimming, Madlen, Demmelmair, Hans, Koletzko, Berthold, Warschburger, Petra, Blanke, Katharina, Reischl, Eva, Kalhoff, Hermann, Kersting, Mathilde
Format: Article
Language:English
Subjects:
Adult
alpha-Linolenic Acid - administration & dosage
alpha-Linolenic Acid - blood
Animals
Canola Oil
Chemistry
Chemistry and Materials Science
Cross-Sectional Studies
Diet
Docosahexaenoic Acids - administration & dosage
Docosahexaenoic Acids - blood
Eicosapentaenoic Acid - administration & dosage
Eicosapentaenoic Acid - blood
Erythrocytes - metabolism
Fatty Acid Desaturases - genetics
Female
Fishes
Glycerophospholipids - blood
Humans
Infant
Infant Nutritional Physiological Phenomena
Linoleic Acid - administration & dosage
Linoleic Acid - blood
Male
Multigene Family
Nutrition
Nutritional Status
Original Contribution
Plant Oils - administration & dosage
Polymorphism, Single Nucleotide
Seafood
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Summary:Purpose Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status. Methods Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids. Results Complete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-015-0982-2