Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia

Highlights • Hypoxic preconditioning increased latency to pilocarpine-induced status epilepticus. • Preconditioned rats had better memory performance than non-preconditioned group. • Neuropathological changes were milder in preconditioned animals submitted to status.

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Bibliographic Details
Published in:Neuroscience 2016-09, Vol.332, p.88-100
Main Authors: Do Val-da Silva, Raquel Araujo, Peixoto-Santos, José Eduardo, Scandiuzzi, Renata Caldo, Balista, Priscila Alves, Bassi, Mirian, Glass, Mogens Lesner, Romcy-Pereira, Rodrigo Neves, Galvis-Alonso, Orfa Yineth, Leite, João Pereira
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Hippocampus - pathology
hypoxic preconditioning
Ischemic Preconditioning
Male
memory deficit
Memory Disorders - pathology
Memory Disorders - prevention & control
mossy fiber sprouting
Neurology
neuronal death
Neurons - pathology
Neuroprotection
Pilocarpine
pilocarpine-induced status epilepticus
Rats, Wistar
Spatial Memory
Status Epilepticus - pathology
Status Epilepticus - psychology
Status Epilepticus - therapy
temporal lobe epilepsy
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Description
Summary:Highlights • Hypoxic preconditioning increased latency to pilocarpine-induced status epilepticus. • Preconditioned rats had better memory performance than non-preconditioned group. • Neuropathological changes were milder in preconditioned animals submitted to status.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.06.047