Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia

We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro . GDNF (1 ng/ml) partially neutralized the negative effects of hypo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-05, Vol.161 (1), p.168-174
Main Authors: Vedunova, M. V., Shishkina, T. V., Mishchenko, T. A., Mitroshina, E. V., Astrakhanova, T. A., Pimashkin, A. S., Mukhina, I. V.
Format: Article
Language:English
Subjects:
Animals
Artificial neural networks
Biomedical and Life Sciences
Biomedicine
Calcium Signaling
Cell Biology
Cell Hypoxia
Cell Survival
Cells, Cultured
Glial Cell Line-Derived Neurotrophic Factor - pharmacology
Glial Cell Line-Derived Neurotrophic Factor - physiology
Hippocampus - cytology
Internal Medicine
Laboratory Medicine
Mice, Inbred C57BL
Neurons - physiology
Neurophysiology
Neuroprotective Agents - pharmacology
Pathology
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Summary:We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro . GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3369-3