Mosquito gut antiparasitic and antiviral immunity

Mosquitoes are responsible for the transmission of diseases with a serious impact on global human health, such as malaria and dengue. All mosquito-transmitted pathogens complete part of their life cycle in the insect gut, where they are exposed to mosquito-encoded barriers and active factors that ca...

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Bibliographic Details
Published in:Developmental and comparative immunology 2016-11, Vol.64, p.53-64
Main Authors: Saraiva, Raúl G., Kang, Seokyoung, Simões, Maria L., Angleró-Rodríguez, Yesseinia I., Dimopoulos, George
Format: Article
Language:English
Subjects:
Animals
Culicidae
Culicidae - immunology
Dengue
Disease Transmission, Infectious - prevention & control
Filariasis - immunology
Host-Pathogen Interactions
Immunity, Innate
Innate immunity
Intestines - immunology
Intestines - microbiology
Life Cycle Stages
Microbiota
Mosquito
Mosquito Vectors
Parasitic Diseases, Animal - immunology
Plasmodium
Virus Diseases - immunology
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Summary:Mosquitoes are responsible for the transmission of diseases with a serious impact on global human health, such as malaria and dengue. All mosquito-transmitted pathogens complete part of their life cycle in the insect gut, where they are exposed to mosquito-encoded barriers and active factors that can limit their development. Here we present the current understanding of mosquito gut immunity against malaria parasites, filarial worms, and viruses such as dengue, Chikungunya, and West Nile. The most recently proposed immune mediators involved in intestinal defenses are discussed, as well as the synergies identified between the recognition of gut microbiota and the mounting of the immune response. •The mosquito gut is a major immune organ that plays an important role in fighting infections with human pathogens.•Mosquito intestinal immunity is a significant regulator of vector competence.•The mosquito gut is capable of mounting a variety of defenses against invading pathogens.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2016.01.015