Long-Term Outcomes Following Transvenous Lead Extraction

• Published in: Pacing and clinical electrophysiology 2016-04, Vol.39 (4), p.345-351
• Main Authors: GOMES, SEAN, CRANNEY, GREGORY, BENNETT, MICHAEL, GILES, ROBERT
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Australia - epidemiology; Catheterization, Peripheral - mortality; Cohort Studies; Comorbidity; Device Removal - mortality; Electrodes, Implanted - statistics & numerical data; Female; Hospital Mortality; Humans; Incidence; infection; internal cardioverter defibrillator; Kidney Diseases - mortality; lead extraction; Longitudinal Studies; Male; Middle Aged; pacemaker; Pacemaker, Artificial - supply & distribution; Postoperative Complications - mortality; Risk Factors; Sex Distribution; Survival Rate; Treatment Outcome; Young Adult
• ISSN: 0147-8389; 1540-8159
• DOI: 10.1111/pace.12812

Background Complications related to a cardiac implantable electronic device sometimes require transvenous lead extraction (TLE). We report long‐term follow‐up of patients undergoing TLE, particularly mortality, recurrent device infection, and need for repeat procedures. Methods and Results Consecutive patients undergoing TLE at a high‐volume center were assessed for characteristics, indications, and outcomes. One thousand and six leads were extracted from 510 patients. Clinical success rate was 98.2% and complete procedural success was 92.2%, with one intraprocedural death. The mean follow‐up was 5.5 +/− 4.9 years (range 0.2–18 years). Cumulative mortality was 3.3% at 30 days, 7.7% at 6 months, 10.0% at 1 year, and 33.0% at 10 years. Factors associated with increased long‐term mortality included cardiac device infection (CDI; 33% vs 17% for non‐CDI; χ² 13.8, P = 0.0003), procedural complications (43% vs 27% for no complications; χ² 4.2, P = 0.04), age (75.0 +/− 10.9 years in patients who died vs 62.7 +/− 17.2 years; P < 0.0001), and impaired renal function (creatinine 142.5 +/− 106.4 μmol/L in patients who died vs 106.3 +/− 90.7 μmol/L; P = 0.001). The rate of CDI after TLE was 3.9% (mean 11.6 months post extraction, range 0.3–84 months) and is higher in patients with retained lead fragments (13.5% vs 3.0% with complete removal; χ² 10.7, P = 0.001). Conclusion Long‐term mortality following TLE is high, particularly in those with systemic infection, procedural complications, advanced age, and renal impairment. Retained fragments are a risk factor for CDI post extraction.