Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China

Emission of polycyclic aromatic hydrocarbons (PAHs) from e-waste recycling activities in China is known. However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated pol...

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Published in:Environment international 2016-09, Vol.94, p.161-169
Main Authors: Lu, Shao-you, Li, Yan-xi, Zhang, Jian-qing, Zhang, Tao, Liu, Gui-hua, Huang, Ming-zhi, Li, Xiao, Ruan, Ju-jun, Kannan, Kurunthachalam, Qiu, Rong-liang
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Language:English
Subjects:
8-hydroxy-2′-deoxyguanosine
Adult
Biomarkers - urine
China
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
E-waste recycling
Electronic Waste
Environmental Exposure - adverse effects
Environmental Pollutants - urine
Female
Humans
Male
Malondialdehyde
Malondialdehyde - urine
Middle Aged
Oxidative Stress
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - urine
Recycling
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creator Lu, Shao-you
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Qiu, Rong-liang
description Emission of polycyclic aromatic hydrocarbons (PAHs) from e-waste recycling activities in China is known. However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China. The urinary levels of ∑10OH-PAHs determined in e-waste recycling area (GM: 25.4μg/g Cre) were significantly higher (p
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However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China. The urinary levels of ∑10OH-PAHs determined in e-waste recycling area (GM: 25.4μg/g Cre) were significantly higher (p&lt;0.05) than those found in both rural (11.7μg/g Cre) and urban (10.9μg/g Cre) reference areas. The occupationally exposed e-waste workers (36.6μg/g Cre) showed significantly higher (p&lt;0.01) urinary Σ10OH-PAHs concentrations than non-occupationally exposed people (23.2μg/g Cre) living in the e-waste recycling site. The differences in urinary Σ10OH-PAHs levels between smokers (23.4μg/g Cre) and non-smokers (24.7μg/g Cre) were not significant (p&gt;0.05) in e-waste dismantling sites, while these differences were significant (p&lt;0.05) in rural and urban reference areas; this indicated that smoking is not associated with elevated levels of PAH exposure in e-waste dismantling site. Furthermore, we found that urinary concentrations of Σ10OH-PAHs and individual OH-PAHs were significantly associated with elevated 8-OHdG, in samples collected from e-waste dismantling site; the levels of urinary 1-hydroxypyrene (1-PYR) (r=0.284, p&lt;0.01) was significantly positively associated with MDA. Our results indicate that the exposure to PAHs at the e-waste dismantling site may have an effect on oxidative damage to DNA among selected participants, but this needs to be validated in large studies. [Display omitted] •Associations between PAH exposure and oxidative stress were explored in e-waste recycling area.•E-waste recycling activities contribute to high human exposure to PAHs.•Smoking is not an important contributor to PAH exposure in e-waste dismantling site.•PAH exposure was associated with oxidative damage to DNA.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2016.05.021</identifier><identifier>PMID: 27258657</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>8-hydroxy-2′-deoxyguanosine ; Adult ; Biomarkers - urine ; China ; Deoxyguanosine - analogs &amp; derivatives ; Deoxyguanosine - urine ; E-waste recycling ; Electronic Waste ; Environmental Exposure - adverse effects ; Environmental Pollutants - urine ; Female ; Humans ; Male ; Malondialdehyde ; Malondialdehyde - urine ; Middle Aged ; Oxidative Stress ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - urine ; Recycling</subject><ispartof>Environment international, 2016-09, Vol.94, p.161-169</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-6ca32d8affbba07763255e53837636bab80c377e07bc6af59d18e8cc7b32b1dd3</citedby><cites>FETCH-LOGICAL-c461t-6ca32d8affbba07763255e53837636bab80c377e07bc6af59d18e8cc7b32b1dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27258657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Shao-you</creatorcontrib><creatorcontrib>Li, Yan-xi</creatorcontrib><creatorcontrib>Zhang, Jian-qing</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Liu, Gui-hua</creatorcontrib><creatorcontrib>Huang, Ming-zhi</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Ruan, Ju-jun</creatorcontrib><creatorcontrib>Kannan, Kurunthachalam</creatorcontrib><creatorcontrib>Qiu, Rong-liang</creatorcontrib><title>Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China</title><title>Environment international</title><addtitle>Environ Int</addtitle><description>Emission of polycyclic aromatic hydrocarbons (PAHs) from e-waste recycling activities in China is known. However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China. The urinary levels of ∑10OH-PAHs determined in e-waste recycling area (GM: 25.4μg/g Cre) were significantly higher (p&lt;0.05) than those found in both rural (11.7μg/g Cre) and urban (10.9μg/g Cre) reference areas. The occupationally exposed e-waste workers (36.6μg/g Cre) showed significantly higher (p&lt;0.01) urinary Σ10OH-PAHs concentrations than non-occupationally exposed people (23.2μg/g Cre) living in the e-waste recycling site. The differences in urinary Σ10OH-PAHs levels between smokers (23.4μg/g Cre) and non-smokers (24.7μg/g Cre) were not significant (p&gt;0.05) in e-waste dismantling sites, while these differences were significant (p&lt;0.05) in rural and urban reference areas; this indicated that smoking is not associated with elevated levels of PAH exposure in e-waste dismantling site. Furthermore, we found that urinary concentrations of Σ10OH-PAHs and individual OH-PAHs were significantly associated with elevated 8-OHdG, in samples collected from e-waste dismantling site; the levels of urinary 1-hydroxypyrene (1-PYR) (r=0.284, p&lt;0.01) was significantly positively associated with MDA. Our results indicate that the exposure to PAHs at the e-waste dismantling site may have an effect on oxidative damage to DNA among selected participants, but this needs to be validated in large studies. 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However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China. The urinary levels of ∑10OH-PAHs determined in e-waste recycling area (GM: 25.4μg/g Cre) were significantly higher (p&lt;0.05) than those found in both rural (11.7μg/g Cre) and urban (10.9μg/g Cre) reference areas. The occupationally exposed e-waste workers (36.6μg/g Cre) showed significantly higher (p&lt;0.01) urinary Σ10OH-PAHs concentrations than non-occupationally exposed people (23.2μg/g Cre) living in the e-waste recycling site. The differences in urinary Σ10OH-PAHs levels between smokers (23.4μg/g Cre) and non-smokers (24.7μg/g Cre) were not significant (p&gt;0.05) in e-waste dismantling sites, while these differences were significant (p&lt;0.05) in rural and urban reference areas; this indicated that smoking is not associated with elevated levels of PAH exposure in e-waste dismantling site. Furthermore, we found that urinary concentrations of Σ10OH-PAHs and individual OH-PAHs were significantly associated with elevated 8-OHdG, in samples collected from e-waste dismantling site; the levels of urinary 1-hydroxypyrene (1-PYR) (r=0.284, p&lt;0.01) was significantly positively associated with MDA. Our results indicate that the exposure to PAHs at the e-waste dismantling site may have an effect on oxidative damage to DNA among selected participants, but this needs to be validated in large studies. [Display omitted] •Associations between PAH exposure and oxidative stress were explored in e-waste recycling area.•E-waste recycling activities contribute to high human exposure to PAHs.•Smoking is not an important contributor to PAH exposure in e-waste dismantling site.•PAH exposure was associated with oxidative damage to DNA.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27258657</pmid><doi>10.1016/j.envint.2016.05.021</doi><tpages>9</tpages></addata></record>
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subjects 8-hydroxy-2′-deoxyguanosine
Adult
Biomarkers - urine
China
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
E-waste recycling
Electronic Waste
Environmental Exposure - adverse effects
Environmental Pollutants - urine
Female
Humans
Male
Malondialdehyde
Malondialdehyde - urine
Middle Aged
Oxidative Stress
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - urine
Recycling
title Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China
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