Comparison of Clinical Features in Blacks Versus Whites With Hypertrophic Cardiomyopathy

To date, there has not been a large systematic examination of the hypertrophic cardiomyopathy (HC) phenotype in blacks versus whites. In this study, we investigate differences in presentation of HC between blacks and whites. We included 441 consecutive patients with HC seen at the Johns Hopkins HC c...

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Bibliographic Details
Published in:The American journal of cardiology 2016-06, Vol.117 (11), p.1815-1820
Main Authors: Sorensen, Lars L., MD, PhD, Pinheiro, Aurelio, MD, PhD, Dimaano, Veronica Lea, MD, Pozios, Iraklis, MD, Nowbar, Alexandra, MBBS, BSc, Liu, Hongyun, MD, Luo, Hong-Chang, MD, Lin, Xiaoping, MD, Olsen, Niels T., MD, PhD, Hansen, Thomas F., MD, Sogaard, Peter, MD, DMSc, Abraham, Maria R., MD, Abraham, Theodore P., MD
Format: Article
Language:English
Subjects:
African Americans
Cardiac arrhythmia
Cardiology
Cardiomyopathy
Cardiomyopathy, Hypertrophic - diagnosis
Cardiomyopathy, Hypertrophic - ethnology
Cardiomyopathy, Hypertrophic - physiopathology
Cardiovascular
Cross-Sectional Studies
Echocardiography
Electrocardiography
European Continental Ancestry Group
Female
Follow-Up Studies
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Hypertension
Male
Maryland - epidemiology
Middle Aged
Morbidity - trends
Phenotype
Prognosis
Prospective Studies
Registries
Time Factors
Ultrasonic imaging
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Summary:To date, there has not been a large systematic examination of the hypertrophic cardiomyopathy (HC) phenotype in blacks versus whites. In this study, we investigate differences in presentation of HC between blacks and whites. We included 441 consecutive patients with HC seen at the Johns Hopkins HC clinic in the period from February 2005 to June 2012. We compared 76 blacks for clinical presentation, electrocardiogram, exercise capacity, left ventricular morphology, and hemodynamics by echocardiography to 365 whites. Black patients with HC more often presented with abnormal electrocardiogram (93% vs 80%, p = 0.009), driven by a significant difference in repolarization abnormalities (79% vs 56%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.03.017