Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis

Abstract To compare pro-inflammatory cytokine profiles and kinetics in patients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and com...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2016-08, Vol.169, p.8-13
Main Authors: Inoue, Natsumi, Shimizu, Masaki, Tsunoda, Shinichiro, Kawano, Mitsuhiro, Matsumura, Masami, Yachie, Akihiro
Format: Article
Language:English
Subjects:
Adult
Adult-onset Still's disease
Aged
Aged, 80 and over
Allergy and Immunology
Anti-Inflammatory Agents - therapeutic use
Arthritis, Juvenile - blood
Arthritis, Juvenile - complications
Arthritis, Juvenile - drug therapy
Child
Child, Preschool
Cytokines - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-18
Interleukin-18 - blood
Interleukin-6 - blood
Macrophage activation syndrome
Macrophage Activation Syndrome - blood
Macrophage Activation Syndrome - complications
Macrophage Activation Syndrome - drug therapy
Male
Middle Aged
Prednisolone - therapeutic use
Still's Disease, Adult-Onset - blood
Still's Disease, Adult-Onset - complications
Still's Disease, Adult-Onset - drug therapy
Systemic juvenile idiopathic arthritis
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Summary:Abstract To compare pro-inflammatory cytokine profiles and kinetics in patients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18. Distinct IL-6- and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2016.05.010