Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls

Perfluorinated compounds (PFCs) are ubiquitous in the environment and have been detected in humans and wildlife. Exposure to PFCs has decreased in the United States recently, while exposure to PFCs continues in Asian countries, which represents a public health concern. Various mechanisms by which PF...

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Bibliographic Details
Published in:Environment international 2016-09, Vol.94, p.607-613
Main Authors: Shah-Kulkarni, Surabhi, Kim, Byung-Mi, Hong, Yun-Chul, Kim, Hae Soon, Kwon, Eun Jin, Park, Hyesook, Kim, Young Ju, Ha, Eun-Hee
Format: Article
Language:English
Subjects:
Female
Fluorocarbons - adverse effects
Girls
Humans
Infant, Newborn
Maternal Exposure - statistics & numerical data
Perfluorinated compounds
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Retrospective Studies
Thyroid hormones
Thyroid Hormones - blood
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Summary:Perfluorinated compounds (PFCs) are ubiquitous in the environment and have been detected in humans and wildlife. Exposure to PFCs has decreased in the United States recently, while exposure to PFCs continues in Asian countries, which represents a public health concern. Various mechanisms by which PFCs affect fetal growth have been proposed, such as activation of peroxisome proliferators, disruption of thyroid hormones and changes in lipid metabolism. However, the overall evidence for an association with thyroid hormones is not strong. Therefore, we examined the effect of various prenatal PFCs on cord blood thyroid hormones: triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) levels, and explored the endocrine disrupting effect of these PFCs on thyroid hormone levels in children according to gender. Two hundred and seventy-nine study participants were selected from among the enrolled participants in the Ewha Birth & Growth Retrospective Cohort, a retrospective birth cohort study conducted at Ewha Womans University Hospital, Seoul, Korea between 2006 and 2010. A generalized linear model was constructed to explore the association of PFCs and thyroid hormones. Further, an analysis stratified by gender was conducted. Our study shows that cord blood perfluoro n-pentanoic acid (PFPeA) was positively associated with cord blood T4 (p=0.01) level. Gender-specific analysis showed that prenatal PFCs: PFPeA and Perfluorohexane sulfonic acid (PFHxS) exposure significantly increased T4 (p
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2016.06.024