Vagal nerve stimulation attenuates IL-6 and TNFα expression in respiratory regions of the developing rat brainstem

Highlights • Interleukin-6 (IL-6) is up-regulated in the brainstem via intratracheal injection of Lipopolysaccharide (LPS). • Tumor necrosis factor alpha (TNFα) is also up-regulated in the brainstem via intratracheal injection of LPS. • Vagal nerve stimulation (VNS) attenuates the up-regulation of t...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2016-07, Vol.229, p.1-4
Main Authors: Johnson, Rhaya L, Murray, Samuel T, Camacho, David K, Wilson, Christopher G
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Brain Stem - growth & development
Brain Stem - metabolism
Brain Stem - pathology
Disease Models, Animal
Immunohistochemistry
Inflammation
Inflammation - metabolism
Inflammation - pathology
Inflammation - therapy
Interleukin-6 - metabolism
Lipopolysaccharides
Medical Education
Pulmonary/Respiratory
Rats, Sprague-Dawley
Respiratory control
Respiratory Tract Infections - metabolism
Respiratory Tract Infections - pathology
Respiratory Tract Infections - therapy
Trachea - immunology
Tumor Necrosis Factor-alpha - metabolism
Up-Regulation
Vagus nerve
Vagus Nerve Stimulation
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Summary:Highlights • Interleukin-6 (IL-6) is up-regulated in the brainstem via intratracheal injection of Lipopolysaccharide (LPS). • Tumor necrosis factor alpha (TNFα) is also up-regulated in the brainstem via intratracheal injection of LPS. • Vagal nerve stimulation (VNS) attenuates the up-regulation of these cytokines after LPS.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2016.03.014