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Vagal nerve stimulation attenuates IL-6 and TNFα expression in respiratory regions of the developing rat brainstem

Highlights • Interleukin-6 (IL-6) is up-regulated in the brainstem via intratracheal injection of Lipopolysaccharide (LPS). • Tumor necrosis factor alpha (TNFα) is also up-regulated in the brainstem via intratracheal injection of LPS. • Vagal nerve stimulation (VNS) attenuates the up-regulation of t...

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Published in:	Respiratory physiology & neurobiology 2016-07, Vol.229, p.1-4
Main Authors:	Johnson, Rhaya L, Murray, Samuel T, Camacho, David K, Wilson, Christopher G
Format:	Article
Language:	English
Subjects:	Animals Animals, Newborn Brain Stem - growth & development Brain Stem - metabolism Brain Stem - pathology Disease Models, Animal Immunohistochemistry Inflammation Inflammation - metabolism Inflammation - pathology Inflammation - therapy Interleukin-6 - metabolism Lipopolysaccharides Medical Education Pulmonary/Respiratory Rats, Sprague-Dawley Respiratory control Respiratory Tract Infections - metabolism Respiratory Tract Infections - pathology Respiratory Tract Infections - therapy Trachea - immunology Tumor Necrosis Factor-alpha - metabolism Up-Regulation Vagus nerve Vagus Nerve Stimulation
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creator	Johnson, Rhaya L Murray, Samuel T Camacho, David K Wilson, Christopher G
description	Highlights • Interleukin-6 (IL-6) is up-regulated in the brainstem via intratracheal injection of Lipopolysaccharide (LPS). • Tumor necrosis factor alpha (TNFα) is also up-regulated in the brainstem via intratracheal injection of LPS. • Vagal nerve stimulation (VNS) attenuates the up-regulation of these cytokines after LPS.
doi_str_mv	10.1016/j.resp.2016.03.014
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subjects	Animals Animals, Newborn Brain Stem - growth & development Brain Stem - metabolism Brain Stem - pathology Disease Models, Animal Immunohistochemistry Inflammation Inflammation - metabolism Inflammation - pathology Inflammation - therapy Interleukin-6 - metabolism Lipopolysaccharides Medical Education Pulmonary/Respiratory Rats, Sprague-Dawley Respiratory control Respiratory Tract Infections - metabolism Respiratory Tract Infections - pathology Respiratory Tract Infections - therapy Trachea - immunology Tumor Necrosis Factor-alpha - metabolism Up-Regulation Vagus nerve Vagus Nerve Stimulation
title	Vagal nerve stimulation attenuates IL-6 and TNFα expression in respiratory regions of the developing rat brainstem
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