Motor unit number estimation as a complementary test to routine electromyography in the diagnosis of amyotrophic lateral sclerosis

• Published in: Journal of electromyography and kinesiology 2016-02, Vol.26, p.60-65
• Main Authors: Gawel, Malgorzata, Zalewska, Ewa, Lipowska, Marta, Kostera-Pruszczyk, Anna, Szmidt-Salkowska, Elzbieta, Kaminska, Anna
• Format: Article
• Language: English
• Subjects: Abducens Nerve - physiopathology; Action Potentials - physiology; Adult; Aged; Aged, 80 and over; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - physiopathology; Electromyography; Electromyography - methods; Female; Foot - physiopathology; Humans; Male; Middle Aged; Motor Neurons - physiology; Motor unit number estimation; Muscle Strength - physiology; Muscle, Skeletal - physiopathology; Physical Medicine and Rehabilitation; Recruitment, Neurophysiological - physiology
• ISSN: 1050-6411; 1873-5711
• DOI: 10.1016/j.jelekin.2015.11.001

Abstract Electromyographic (EMG) abnormalities that reveal denervation and reinnervation caused by lower motor neuron degeneration do not reflect the number of motor units that determines muscle strength. Consequently, motor unit activity potential (MUAP) parameters do not reflect muscle dysfunction. The aim of the study was to compare the value of motor unit number estimation (MUNE) and MUAP parameters as indicators of clinical muscle dysfunction in patients with amyotrophic lateral sclerosis (ALS), and to analyze the role of MUNE as a supplement to the EMG criteria for the diagnosis of ALS. In 25 patients with ALS, MUNE by the multipoint incremental method in the abductor digiti minimi (ADM) and quantitative EMG in the first dorsal interosseous (FDI) were obtained. The Medical Research Council (MRC) scale was used to evaluate clinical muscle dysfunction. A strong correlation between the number of motor units evaluated by MUNE and ADM clinical function by the MRC scale was found ( P < 0.001). An increased value of surface-detected single motor action potential was associated with a decreased MRC score for ADM ( P < 0.1). No relation was found between MUAP parameters in FDI and MRC scores. Our data support the value of the MUNE method for the detection of motor unit loss in ALS, and it could be postulated that MUNE studies may be considered complementary tests for ALS in a future revision of ALS criteria.