Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract

•Consumption of 500mg aronia berry extract increased plasma and urine polyphenols.•Peonidin-3-O-galactoside was a significant anthocyanin metabolite in plasma and urine.•Anthocyanins and colonic catabolite tmax values were from 1 to 6.3h.•Colonic polyphenol catabolites exceeded anthocyanin precursor...

Full description

Saved in:
Bibliographic Details
Published in:Food chemistry 2016-11, Vol.211, p.860-868
Main Authors: Xie, Liyang, Lee, Sang Gil, Vance, Terrence M., Wang, Ying, Kim, Bohkyung, Lee, Ji-Young, Chun, Ock K., Bolling, Bradley W.
Format: Article
Language:English
Subjects:
Adult
Anthocyanin
Anthocyanins - administration & dosage
Anthocyanins - metabolism
Aronia
Biological Availability
Colon - metabolism
Cyanidin
Eating - physiology
Female
Ferulic acid
Fruit - chemistry
Fruit - metabolism
Humans
Male
Metabolism
Middle Aged
Pharmacokinetic
Photinia - metabolism
Pilot Projects
Plant Extracts - administration & dosage
Plant Extracts - metabolism
Polyphenol
Polyphenols - metabolism
UHPLC-MS
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Consumption of 500mg aronia berry extract increased plasma and urine polyphenols.•Peonidin-3-O-galactoside was a significant anthocyanin metabolite in plasma and urine.•Anthocyanins and colonic catabolite tmax values were from 1 to 6.3h.•Colonic polyphenol catabolites exceeded anthocyanin precursors in plasma and urine. A single-dose pharmacokinetic trial was conducted in 6 adults to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of 500mg aronia berry extract. UHPLC-MS methods were developed to quantitate aronia berry polyphenols and their metabolites in plasma and urine. While anthocyanins were bioavailable, microbial phenolic catabolites increased ∼10-fold more than anthocyanins in plasma and urine. Among the anthocyanins, cyanidin-3-O-galactoside was rapidly metabolized to peonidin-3-O-galactoside. Aronia polyphenols were absorbed and extensively metabolized with tmax of anthocyanins and other polyphenol catabolites from 1.0h to 6.33h in plasma and urine. Despite significant inter-individual variation in pharmacokinetic parameters, concentrations of polyphenol metabolites in plasma and urine at 24h were positively correlated with total AUC in plasma and urine (r=0.93, and r=0.98, respectively). This suggests that fasting blood and urine collections could be used to estimate polyphenol bioavailability and metabolism after aronia polyphenol consumption.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2016.05.122