Case of late-onset bleb associated endophthalmitis caused by Rothia mucilaginosa

Abstract Rothia mucilaginosa is a gram-positive coagulase-negative coccus of the family Micrococcaceae . Although R. mucilaginosa forms part of the oropharyngeal microflora, it has only recently been isolated in ocular infections. We report a case of a 41-year-old man who developed late-onset bleb-r...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2016-09, Vol.22 (9), p.645-647
Main Authors: Oie, Shinya, MD, Mochizuki, Kiyofumi, MD, PhD, Ishida, Kyoko, MD, PhD, Nakayama, Asami, Ohkusu, Kiyofumi, PhD
Format: Article
Language:English
Subjects:
Actinomycetales Infections - diagnosis
Adult
Blister - etiology
Blister - microbiology
Conjunctival Diseases - diagnosis
Conjunctival Diseases - microbiology
Endophthalmitis - diagnosis
Endophthalmitis - microbiology
Genes, rRNA
Glaucoma - complications
Hematology, Oncology and Palliative Medicine
Humans
Late-onset bleb-related endophthalmitis
Male
Micrococcaceae - genetics
Micrococcaceae - isolation & purification
Rothia mucilaginosa
Sequence analysis
Sequence Analysis, RNA - methods
Trabeculectomy - adverse effects
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Summary:Abstract Rothia mucilaginosa is a gram-positive coagulase-negative coccus of the family Micrococcaceae . Although R. mucilaginosa forms part of the oropharyngeal microflora, it has only recently been isolated in ocular infections. We report a case of a 41-year-old man who developed late-onset bleb-related endophthalmitis (BRE). He had undergone glaucoma surgery 21 years earlier and had a thin-walled cystic bleb prior to the development of endophthalmitis in his right eye. He immediately received intravitreal injections of ceftazidime and vancomycin, topical levofloxacin and cefmenoxime, and intravenous cefozopran. Culture of the aqueous humor specimen identified Rothia mucilaginosa by 16S rRNA sequence analysis. To our knowledge, this is the first report of late-onset BRE caused by R. mucilaginosa . Our case indicate that R. mucilaginosa can be a cause of late-onset BRE, and that molecular analysis is an accurate method to identify R. mucilaginosa.
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2016.02.007