Visible Light Photocatalytic Radical–Radical Cross-Coupling Reactions of Amines and Carbonyls: A Route to 1,2-Amino Alcohols

An intermolecular radical–radical cross-coupling reaction of secondary and tertiary amines with aryl ketones and aldehydes has been developed using visible light photoredox catalysis. This reaction provides an efficient and straightforward approach to some useful 1,2-amino alcohols in moderate to go...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-08, Vol.81 (16), p.7237-7243
Main Authors: Ding, Wei, Lu, Liang-Qiu, Liu, Jing, Liu, Dan, Song, Hai-Tao, Xiao, Wen-Jing
Format: Article
Language:English
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Summary:An intermolecular radical–radical cross-coupling reaction of secondary and tertiary amines with aryl ketones and aldehydes has been developed using visible light photoredox catalysis. This reaction provides an efficient and straightforward approach to some useful 1,2-amino alcohols in moderate to good yields under mild conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b01217