A Comparative Study of the Photosensitizer Penetration into Artificial Caries Lesions in Dentin Measured by the Confocal Raman Microscopy

This study utilized the confocal Raman microspectroscopy (CRM) technique for the first time to investigate the degree of the penetration of toluidine blue‐orto (TBO) in artificial caries lesions produced by two distinct caries‐inducing models. The dentin specimens (n = 10) were divided into three gr...

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Bibliographic Details
Published in:Photochemistry and photobiology 2014-01, Vol.90 (1), p.183-188
Main Authors: Melo, Mary Anne S., Rolim, Juliana P.M.L., Zanin, Iriana C.J., Silva, José J.A., Paschoal, Alexandre R., Ayala, Alejandro P., Rodrigues, Lidiany K.A.
Format: Article
Language:English
Subjects:
Comparative studies
Dental caries
Dental Caries - metabolism
Dentin - drug effects
Dentin - metabolism
Dentin - pathology
Dyes
Humans
Microhardness
Microscopy
Microscopy, Confocal
Models, Biological
Photodynamic therapy
Photosensitizing Agents - metabolism
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Summary:This study utilized the confocal Raman microspectroscopy (CRM) technique for the first time to investigate the degree of the penetration of toluidine blue‐orto (TBO) in artificial caries lesions produced by two distinct caries‐inducing models. The dentin specimens (n = 10) were divided into three groups: control, in vitro and in situ. Thereafter, the lesion depth and the demineralization level were evaluated by cross‐sectional microhardness (CSMH). CRM mapping across the dentin surface was assessed after the dye application. The CSMH and CRM data were analyzed by t‐test and ANOVA, respectively (P 
ISSN:0031-8655
1751-1097
DOI:10.1111/php.12186