Thermal Cycloisomerization of Putative Allenylpyridines for the Synthesis of Isoquinoline Derivatives

A cascade (cyclo)­isomerization/elimination process produces novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research. Mechanistic experiments support a putative allenylpyridine (reminiscent of the Garratt–Braverman cyclization) as a key interm...

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Bibliographic Details
Published in:Organic letters 2016-08, Vol.18 (16), p.4104-4107
Main Authors: Morrison, Alec E, Hrudka, Jeremy J, Dudley, Gregory B
Format: Article
Language:English
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Summary:A cascade (cyclo)­isomerization/elimination process produces novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research. Mechanistic experiments support a putative allenylpyridine (reminiscent of the Garratt–Braverman cyclization) as a key intermediate in the cascade process.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b02034