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Impact of cytomegalovirus intestinal disease on the prognosis in patients with severe intestinal graft- versus- host disease
To explore risk factors, clinical characteristics and prognosis of CMV enteritis combined with severe intestinal graft- versus- host disease (GVHD). The data of 80 intestinal grade Ⅲ/Ⅳ GVHD patients from January 2005 to September 2015 in hematology of PKUPH were retrospectively analyzed. All patient...
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| Published in: | Zhōnghuá xuèyèxué zázhì 2016-07, Vol.37 (7), p.597 |
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| Language: | Chinese |
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| container_issue | 7 |
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| container_title | Zhōnghuá xuèyèxué zázhì |
| container_volume | 37 |
| creator | Liu, Y Mo, X D Han, T T Xu, L P Zhang, X H Wang, Y Liu, K Y Huang, X J |
| description | To explore risk factors, clinical characteristics and prognosis of CMV enteritis combined with severe intestinal graft- versus- host disease (GVHD).
The data of 80 intestinal grade Ⅲ/Ⅳ GVHD patients from January 2005 to September 2015 in hematology of PKUPH were retrospectively analyzed. All patients received colonoscopy and all GVHD diagnoses were based on clinical manifestation, colonoscopy and biopsies. All patients were divided into biopsy- proven CMV enteritis and control groups. Various characteristics, clinical manifestation and transplantation related mortality were compared.
A total of 18 patients were diagnosed with biopsy- proven CMV enteritis, including 14 antigens positive, 2 inclusion bodies positive (1 positive for both antigen and inclusion body) and 3 intestinal mucosa CMV PCR positive. The median diagnosis time for CMV enteritis was 65 days (range, 27 to 278 days) after transplantation. There was no statistically difference for baseline (age, gender, underlying disease, status of disease, et |
| doi_str_mv | 10.3760/cma.j.issn.0253-2727.2016.07.011 |
| format | article |
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The data of 80 intestinal grade Ⅲ/Ⅳ GVHD patients from January 2005 to September 2015 in hematology of PKUPH were retrospectively analyzed. All patients received colonoscopy and all GVHD diagnoses were based on clinical manifestation, colonoscopy and biopsies. All patients were divided into biopsy- proven CMV enteritis and control groups. Various characteristics, clinical manifestation and transplantation related mortality were compared.
A total of 18 patients were diagnosed with biopsy- proven CMV enteritis, including 14 antigens positive, 2 inclusion bodies positive (1 positive for both antigen and inclusion body) and 3 intestinal mucosa CMV PCR positive. The median diagnosis time for CMV enteritis was 65 days (range, 27 to 278 days) after transplantation. There was no statistically difference for baseline (age, gender, underlying disease, status of disease, et</description><identifier>ISSN: 0253-2727</identifier><identifier>DOI: 10.3760/cma.j.issn.0253-2727.2016.07.011</identifier><identifier>PMID: 27535861</identifier><language>chi</language><publisher>China</publisher><subject>Cytomegalovirus ; Cytomegalovirus Infections - diagnosis ; Enteritis - diagnosis ; Enteritis - virology ; Graft vs Host Disease - diagnosis ; Graft vs Host Disease - virology ; Humans ; Intestines - pathology ; Polymerase Chain Reaction ; Prognosis ; Retrospective Studies ; Risk Factors</subject><ispartof>Zhōnghuá xuèyèxué zázhì, 2016-07, Vol.37 (7), p.597</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27535861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>Mo, X D</creatorcontrib><creatorcontrib>Han, T T</creatorcontrib><creatorcontrib>Xu, L P</creatorcontrib><creatorcontrib>Zhang, X H</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Liu, K Y</creatorcontrib><creatorcontrib>Huang, X J</creatorcontrib><title>Impact of cytomegalovirus intestinal disease on the prognosis in patients with severe intestinal graft- versus- host disease</title><title>Zhōnghuá xuèyèxué zázhì</title><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><description>To explore risk factors, clinical characteristics and prognosis of CMV enteritis combined with severe intestinal graft- versus- host disease (GVHD).
The data of 80 intestinal grade Ⅲ/Ⅳ GVHD patients from January 2005 to September 2015 in hematology of PKUPH were retrospectively analyzed. All patients received colonoscopy and all GVHD diagnoses were based on clinical manifestation, colonoscopy and biopsies. All patients were divided into biopsy- proven CMV enteritis and control groups. Various characteristics, clinical manifestation and transplantation related mortality were compared.
A total of 18 patients were diagnosed with biopsy- proven CMV enteritis, including 14 antigens positive, 2 inclusion bodies positive (1 positive for both antigen and inclusion body) and 3 intestinal mucosa CMV PCR positive. The median diagnosis time for CMV enteritis was 65 days (range, 27 to 278 days) after transplantation. There was no statistically difference for baseline (age, gender, underlying disease, status of disease, et</description><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>Enteritis - diagnosis</subject><subject>Enteritis - virology</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>Graft vs Host Disease - virology</subject><subject>Humans</subject><subject>Intestines - pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0253-2727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpNkEtrwzAQhHVoaUKav1B0zMWuHrElH0voCwK9tGcjyetExbZcr5wS6I-vS5PSvSwM3wzDELLiLJUqZ7euNel76hG7lIlMJkIJlQrG85SplHF-QeZ_-owsEb1lGZe5lpJdkZlQmcx0zufk67ntjYs01NQdY2hhZ5pw8MOI1HcRMPrONLTyCAaBho7GPdB-CLsuoP9haG-ihy4i_fRxTxEOMMB_724wdUzoJOOICd0HjOe8a3JZmwZhefoL8vZw_7p5SrYvj8-bu23Sc5HHxGlhM2uq6ZQCzitprVN1Jc20RVE5WSi3VsLWfF0IrqQWBlhmeaFrUTmWyQVZ_eZOxT_GqVjZenTQNKaDMGLJNRda61yuJ_TmhI62harsB9-a4VieF5PfIy50Xg</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Liu, Y</creator><creator>Mo, X D</creator><creator>Han, T T</creator><creator>Xu, L P</creator><creator>Zhang, X H</creator><creator>Wang, Y</creator><creator>Liu, K Y</creator><creator>Huang, X J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Impact of cytomegalovirus intestinal disease on the prognosis in patients with severe intestinal graft- versus- host disease</title><author>Liu, Y ; Mo, X D ; Han, T T ; Xu, L P ; Zhang, X H ; Wang, Y ; Liu, K Y ; Huang, X J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-c82b5badddd77e11d3bbc7fd3a3769dc397c472bf149217382ae05b198f2dc053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2016</creationdate><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>Enteritis - diagnosis</topic><topic>Enteritis - virology</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>Graft vs Host Disease - virology</topic><topic>Humans</topic><topic>Intestines - pathology</topic><topic>Polymerase Chain Reaction</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>Mo, X D</creatorcontrib><creatorcontrib>Han, T T</creatorcontrib><creatorcontrib>Xu, L P</creatorcontrib><creatorcontrib>Zhang, X H</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Liu, K Y</creatorcontrib><creatorcontrib>Huang, X J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Y</au><au>Mo, X D</au><au>Han, T T</au><au>Xu, L P</au><au>Zhang, X H</au><au>Wang, Y</au><au>Liu, K Y</au><au>Huang, X J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of cytomegalovirus intestinal disease on the prognosis in patients with severe intestinal graft- versus- host disease</atitle><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><date>2016-07</date><risdate>2016</risdate><volume>37</volume><issue>7</issue><spage>597</spage><pages>597-</pages><issn>0253-2727</issn><abstract>To explore risk factors, clinical characteristics and prognosis of CMV enteritis combined with severe intestinal graft- versus- host disease (GVHD).
The data of 80 intestinal grade Ⅲ/Ⅳ GVHD patients from January 2005 to September 2015 in hematology of PKUPH were retrospectively analyzed. All patients received colonoscopy and all GVHD diagnoses were based on clinical manifestation, colonoscopy and biopsies. All patients were divided into biopsy- proven CMV enteritis and control groups. Various characteristics, clinical manifestation and transplantation related mortality were compared.
A total of 18 patients were diagnosed with biopsy- proven CMV enteritis, including 14 antigens positive, 2 inclusion bodies positive (1 positive for both antigen and inclusion body) and 3 intestinal mucosa CMV PCR positive. The median diagnosis time for CMV enteritis was 65 days (range, 27 to 278 days) after transplantation. There was no statistically difference for baseline (age, gender, underlying disease, status of disease, et</abstract><cop>China</cop><pmid>27535861</pmid><doi>10.3760/cma.j.issn.0253-2727.2016.07.011</doi></addata></record> |
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| identifier | ISSN: 0253-2727 |
| ispartof | Zhōnghuá xuèyèxué zázhì, 2016-07, Vol.37 (7), p.597 |
| issn | 0253-2727 |
| language | chi |
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| source | PubMed Central |
| subjects | Cytomegalovirus Cytomegalovirus Infections - diagnosis Enteritis - diagnosis Enteritis - virology Graft vs Host Disease - diagnosis Graft vs Host Disease - virology Humans Intestines - pathology Polymerase Chain Reaction Prognosis Retrospective Studies Risk Factors |
| title | Impact of cytomegalovirus intestinal disease on the prognosis in patients with severe intestinal graft- versus- host disease |
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