Molecular Targeted Fluorescence-Guided Intraoperative Imaging of Bladder Cancer Nodal Drainage Using Indocyanine Green During Radical and Partial Cystectomy

Optical imaging is a relatively inexpensive, fast, and sensitive addition to a surgeon’s arsenal for the non-invasive detection of malignant dissemination. Optical cameras in the near infrared spectrum are able to successfully identify injected indocyanine green in lymphatic channels and sentinel ly...

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Bibliographic Details
Published in:Current urology reports 2016-10, Vol.17 (10), p.74-74, Article 74
Main Authors: Patel, Manish N., Hemal, Ashok K.
Format: Article
Language:English
Subjects:
Coloring Agents
Cystectomy
Drainage
Fluorescence
Humans
Indocyanine Green
Intraoperative Period
Male
Medicine
Medicine & Public Health
Molecular Targeted Therapy - methods
Nephrology
New Imaging Techniques (A Rastinehad and S Rais-Bahrami
Optical Imaging
Section Editors
Sentinel Lymph Node - pathology
Topical Collection on New Imaging Techniques
Urinary Bladder Neoplasms - pathology
Urology
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Summary:Optical imaging is a relatively inexpensive, fast, and sensitive addition to a surgeon’s arsenal for the non-invasive detection of malignant dissemination. Optical cameras in the near infrared spectrum are able to successfully identify injected indocyanine green in lymphatic channels and sentinel lymph nodes. The use of this technology is now being used in the operating room to help with lymph node dissection and improve the prognosis of patients diagnosed with muscle invasive bladder cancer. Indocyanine green has the potential for many more applications due to its versatility. In the future, there is a potential to use it for lymphangiography during nephroureterctomy for upper tract urothelial carcinoma, adrenal surgery for partial or radical adrenalectomy. Further investigations at multiple centers will validate this technique and its efficiency.
ISSN:1527-2737
1534-6285
DOI:10.1007/s11934-016-0633-z