Effects of Indomethacin on the l‐selectin Expression in Humans

Based on an in vitro study and an uncontrolled in vivo trial we examined the effects of indomethacin on the expression of l‐selectin by leukocytes in healthy volunteers. Eight subjects received infusions of 0.7 mg/kg indomethacin and placebo t.i.d. (three times daily) in a randomized, controlled tri...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2001-11, Vol.54 (5), p.525-527
Main Authors: Dirnberger, E., Albinni, S., Röggla, M., Jilma, B.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Cross-Over Studies
Cyclooxygenase Inhibitors - pharmacology
Cyclooxygenase Inhibitors - toxicity
dexamethasone
Double-Blind Method
Down-Regulation - drug effects
Humans
In Vitro Techniques
indomethacin
Indomethacin - pharmacology
Indomethacin - toxicity
L-selectin
L-Selectin - blood
Leukocytes - drug effects
Leukocytes - immunology
Neutrophils - drug effects
Neutrophils - immunology
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Summary:Based on an in vitro study and an uncontrolled in vivo trial we examined the effects of indomethacin on the expression of l‐selectin by leukocytes in healthy volunteers. Eight subjects received infusions of 0.7 mg/kg indomethacin and placebo t.i.d. (three times daily) in a randomized, controlled trial. Indomethacin decreased the mean fluorescence intensity of the l‐selectin expression on isolated neutrophils incubated with toxic indomethacin concentrations. However, indomethacin did not lower the l‐selectin expression in whole blood or in‐vivo. Thus, therapeutic doses of the cyclo‐oxygenase inhibitor indomethacin do not lower the l‐selectin expression on leukocytes. Hence, the inhibition of cyclo‐oxygenase cannot explain the previously observed dexamethasone‐induced decrease in l‐selectin.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.2001.00995.x