Is there any therapeutic value for the use of histone deacetylase inhibitors for chronic pain?

Highlights • Histone deacetylases (HDAC) are dynamically changed in pain development. • HDAC inhibitors have been demonstrated to have therapeutic effects in pain. • HDAC inhibitors have limitations including non-specificity on targeted genes.

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Bibliographic Details
Published in:Brain research bulletin 2016-07, Vol.125, p.44-52
Main Authors: Wang, Wei, Cuib, Shan-shan, Lu, Rui, Zhang, Hui
Format: Article
Language:English
Subjects:
Animals
Chronic pain
Chronic Pain - drug therapy
Chronic Pain - enzymology
Epigenetic
Histone Deacetylase Inhibitors - therapeutic use
Histone deacetylases
Histone Deacetylases - metabolism
Humans
Inhibitors
Neurology
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Description
Summary:Highlights • Histone deacetylases (HDAC) are dynamically changed in pain development. • HDAC inhibitors have been demonstrated to have therapeutic effects in pain. • HDAC inhibitors have limitations including non-specificity on targeted genes.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.04.010