Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In thi...

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Bibliographic Details
Published in:ACS nano 2016-08, Vol.10 (8), p.7362-7369
Main Authors: Tian, Haijun, Du, Juanjuan, Wen, Jing, Liu, Yang, Montgomery, Scott R, Scott, Trevor P, Aghdasi, Bayan, Xiong, Chengjie, Suzuki, Akinobu, Hayashi, Tetsuo, Ruangchainikom, Monchai, Phan, Kevin, Weintraub, Gil, Raed, Alobaidaan, Murray, Samuel S, Daubs, Michael D, Yang, Xianjin, Yuan, Xu-bo, Wang, Jeffrey C, Lu, Yunfeng
Format: Article
Language:English
Subjects:
Bone Regeneration
Delayed-Action Preparations
Nanocapsules
Polymers
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Summary:Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.5b07950