Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In thi...

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Published in:ACS nano 2016-08, Vol.10 (8), p.7362-7369
Main Authors: Tian, Haijun, Du, Juanjuan, Wen, Jing, Liu, Yang, Montgomery, Scott R, Scott, Trevor P, Aghdasi, Bayan, Xiong, Chengjie, Suzuki, Akinobu, Hayashi, Tetsuo, Ruangchainikom, Monchai, Phan, Kevin, Weintraub, Gil, Raed, Alobaidaan, Murray, Samuel S, Daubs, Michael D, Yang, Xianjin, Yuan, Xu-bo, Wang, Jeffrey C, Lu, Yunfeng
Format: Article
Language:English
Subjects:
Bone Regeneration
Delayed-Action Preparations
Nanocapsules
Polymers
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cited_by cdi_FETCH-LOGICAL-a333t-e35eb5e03ae1457d86625f23e6991ba1dcf44e299515c93ed8c6a9579e0e61873
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container_end_page 7369
container_issue 8
container_start_page 7362
container_title ACS nano
container_volume 10
creator Tian, Haijun
Du, Juanjuan
Wen, Jing
Liu, Yang
Montgomery, Scott R
Scott, Trevor P
Aghdasi, Bayan
Xiong, Chengjie
Suzuki, Akinobu
Hayashi, Tetsuo
Ruangchainikom, Monchai
Phan, Kevin
Weintraub, Gil
Raed, Alobaidaan
Murray, Samuel S
Daubs, Michael D
Yang, Xianjin
Yuan, Xu-bo
Wang, Jeffrey C
Lu, Yunfeng
description Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
doi_str_mv 10.1021/acsnano.5b07950
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Bone Regeneration
Delayed-Action Preparations
Nanocapsules
Polymers
title Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration
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